Malignant transformation in vitro by tryptophan pyrolysis products.
نویسندگان
چکیده
منابع مشابه
Metabolic activation of mutagenic tryptophan pyrolysis products by rat liver microsomes.
In an attempt to determine whether cytochrome P-450 metabolizes tryptophan pyrolysis products, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) and 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) to active forms, studies were done using microsomes and the 9000 x g supernatant (S-9) from polychlorinated biphenyl mixture-treated rat livers together with Salmonella typhimurium TA 98 as a te...
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Model compound studies which were previously done for impurities and environmental residues of chlorophenols and for wastes of chlorination processes were extended to the impurities and pyrolysis products of polychlorinated biphenyls (PCBs). Model compounds were commercial products or synthesized and their structures proven by spectroscopic methods. These models were used as analytical referenc...
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The thermal degradation of tyrosine at a residence time of 0.2s was conducted in a tubular flow reactor in flowing N2 and 4% O2 in N2 for a total pyrolysis time of 3min. The fractional pyrolysis technique, in which the same sample was heated continuously at each pyrolysis temperature, was applied. Thermal decomposition of tyrosine between 350 and 550°C yielded predominantly phenolic compounds (...
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The early incidence of p53 mutation in astrocytomas suggests that it plays an important role in astrocyte transformation. Astrocytes isolated from homozygous p53 knockout mice grow rapidly, lack contact inhibition, and are immortal. Here we tested whether the loss of p53 is sufficient for progression to tumorigenicity of astrocytes. We grew primary astrocytes under three conditions for over 120...
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A line of cells derived from C3H mouse prostate was treated in vitro with methylcholanthrene and transformed to malignancy . Seventeen clones of transformed cells were tested for their immunogenicity in C3H mice. Mice were immunized by production of fibrosarcomas after injection of the individual clones; the tumors were ligated and regressed. Cells of the same clone were injected, and the numbe...
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ژورنال
عنوان ژورنال: Proceedings of the Japan Academy, Series B
سال: 1978
ISSN: 0386-2208,1349-2896
DOI: 10.2183/pjab.54.418